There is a release of norepinephrine within the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors inside the dorsal horn to minimize afferent pain transmission and produce analgesia. For that reason, medicine like clonidine that goal alpha-two receptors can affect the transmission of suffering. Applies to clonidine: oral tablet, https://rudyards479rng6.blogoscience.com/profile