Contraindicated. Cobicistat is really a CYP3A4 inhibitor; contraindicated with CYP3A4 substrates for which elevated plasma concentrations are related to critical and/or life-threatening functions. Simply because CYP3A4 inhibition elevates ergotamine and caffeine serum stages, the risk for vasospasm resulting in cerebral ischemia and/or ischemia in the extremities is improved All medic... https://raymondlfxod.blogsumer.com/28642924/examine-this-report-on-cafergot-discontinued